A Controlled Trial of Choleretic and Hepatoprotective Actions of Livzon and Dehydrocholic
Acid in a Model of Obstructive Jaundice in Albino Rats
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JOHN RATAN1, S.
ROHATGI2, D.K. GUPTA1 and
SIMMI RATAN1
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1Department of Pediatric Surgery, All India Institute of Medical Sciences, New
Delhi 110029, and 2Hind Chemicals, Kanpur, India
The authors have tried to examine the hepatoprotective and cholerectic action of a new
indigenised drug, Livzon (Hind Chemicals Ltd., Kanpur, India) and compared its action to
Decholin (casella-Riedel Pharma GmbH, Frankfurt, Germany), a known hepatoprotective and
choleretic agent. Albino rats were chosen as the experimental animals. Obstructive jaundice
was created by ligating the common bile ducts after taking liver biopsies. The animals were
divided into three groups: (i) Control group-no drug was given, (ii) Livzon trial group, (iii)
Decholin group. The animals were reoperated, liver biopsies were taken and histologically
examined. The study confirmed the hepatoprotective and choleretic actions of Livzon and
Decholin. However, Decholin was more of a choleretic, the Livzon was more
hepatoprotective.
Key word(s)---
biliary obstruction; hepatoprotective; choleretics; Decholin; Livzon
Tohoku J. Exp. Med., 1997, 181, 161-166
Address for reprints:
Dr. D.K. Gupta, M.B.B.S., M.S., M.Ch., Department of Pediatric Surgery, All India Institute
of Medical Sciences, New Delhi lI0029, India.
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