Clinical Significance of 99mTc-DTPA Galactosyl Human Serum Albumin Scintigram in Follow-up
after Kasai Operation
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SATORU SHIMAOKA, RYOJI OHI,
MASAKI NIO, DAIJI IWAMI and
NOBUYUKI SANO
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Department of Pediatric Surgery, Tohoku University, School of Medicine, Sendai 980-77
The scintigram using 99mTechnetium-DTPA galactosyl human serum albumin
(99mTc-GSA) which binds to asialoglycoprotein receptors on hepatocytes is a good index of
hepatocyte function in various liver diseases in adult patients. In 43 patients (4 months to 30 years old) who had
undergone Kasai procedure, we performed 53 series of 99mTc-GSA scintigrams and checked the
laboratory data of blood draw and the clinical status. The indices for blood clearance and liver accumulation were
evaluated on the basis of the dynamic data after 99mTc-GSA injection. HH15 as an index of the
blood clearance, and LHL15 as an index of the accumulation of the hepatocytes were calculated and the
HH15/LHL15 ratio (H/L15) was examined. 99mTc-GSA scintigram correlated with liver function
and clinical status. Our results revealed that 1) The deterioration of the liver functions and clinical status correlates
proportionally with H/L15, 2) The results of 99mTechnetium-GSA scintigram correlate with several
liver function tests, especially direct bilirubin, albumin and choline esterase, 3) This scintigram is an useful index
of clinical status and hepatic function as well as the change of the hepatic parenchymal reserve in BA patients,
especially for the evaluation of liver transplantation.
Key word(s)---
biliary atresia; Kasai operation; asialoglycoprotein receptor; 99mTc-GSA scintigram
Tohoku J. Exp. Med., 1997, 181, 203-211
Address for reprints:
Ryoji Ohi, M.D., Department of Pediatric Surgery, Tohoku University School of Medicine, 1-1 Seiryomachi,
Aoba-ku, Sendai 980-77, Japan.
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