Tohoku J. Exp. Med., 1998, 184 (3)

Case Report

Peripheral Blood Stem Cell Transplantation for Hepatoblastoma with Microscopical Residue: A Therapeutic Approach for Incompletely Resected Tumor

MlYAKO YOSHINARI, MASUE IMAIZUMI, YUTAKA HAYASHI,1 ATSUSHI SATO, TOSHIAKI SAITO, HOSHIRO SUZUKI, TAKAKO SAISHO, DAIKI ABUKAWA, EISHIN OGAWA, JUNICHIRO AIKAWA, KUNIHIKO GOT0,2 TSURUO SATOH,3 RYOJI OHI1 and KAZUlE IINUMA

Department of Pediatries, 1Department of Pediatric Surgery, 2Department of Pathology, Tohoku University School of Medicine, Sendai 980-8574, and 3Department of Pediatrics, Hachinohe City Hospital, Hachinohe 031-8555

  • We report a nine-month-old boy with stage III B hepatoblastoma of caudate lobe origin. Surgical resection was attempted following six courses of chemotherapy, but viable tumor cells remained microscopically at resection margins. Subsequently, he received peripheral blood stem cell transplantation (PBSCT), whose preparative regimen being consisted of carboplatin, etoposide, tetrahydropyranyl adriamycin, and melphalan. Since then, the patient shows no relevance of local relapse or distant metastasis without any chemotherapy. PBSCT for patients with post-operative residue may irnprove the outcome of advanced hepatoblastoma and worth of a further clinical investigation.
    Key words--- microscopic residual hepatoblastoma; caudate lobe origin; megatherapy; peripheral blood stem cell transplantation
    © 1998 Tohoku University Medical Press

    Tohoku J. Exp. Med., 1998, 184, 247-254
    Address for reprints: Masue Imaizumi, M.D., Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-8574, Japan.
    e-mail: mimaizumi@ped.med.tohoku.ac.jp

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