Regular Contributions
a-Adrenergic Blockade in Preventing
Posttransplant Edema of Lung Allograft
- TAKASHI KONDO,
AKIRA HORIKOSHI,
SHIGEFUMI FUJIMURA,
YUJI MATSUMURA,
YOSHINORI OKADA and
KAZUYOSHI SHIMADA
- Department of Thoracic Surgery,
Institute of Development, Aging and Cancer, Tohoku University,
Sendai 980-8575
Effect of a-adrenergic blockers on pulmonary edema in
lung transplantation was studied with a rat model of syngeneic left
lung transplantation. Prior to harvesting, 0.1 mg of Prazocin or 0.4
mg of Yohimbin was given to the donor. Pulmonary and systemic
hemodynamics were measured under the right pulmonary arterial
occlusion (RPAO) at different time points after grafting. Wet to dry
weight ratio (W/D) of all transplants was also calculated. Same
procedure was conducted in rats with normal and ischemic lung and in
transplanted animals without any treatments. While RPAO did not
increase W/D in normal lung with a significant elevation in pulmonary
arterial pressure (PAP), both these values significantly increased in
transplanted lung. Transplanted animals could not tolerate RPAO 24
hours after grafting, but were tolerable later than 48 hours with
elevated W/D and PAP. On the contrary, animals given Prazocin or
Yohimbin were all tolerable at 24 hours postsurgery. Yohimbin
significantly improved W/D. Consequently, it was demonstrated that
pulmonary edema of the graft reached its peak during first 24 to 48
hours after transplantation and was alleviated by the blockade of
a-adrenergic recepter in the graft
vessel.
Key words--- lung transplantation;
reimplantation response; pulmonary edema; a-adrenergic blockade
© 1999 Tohoku University Medical Press
Tohoku J. Exp. Med., 1999,
189, 135-145
Address for reprints: Takashi Kondo, M.D., Department of
Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku
University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan.
e-mail: t-kondo@idac.tohoku.ac.jp
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