Enhancement of Vasoconstrictor Responses to 5-HT but no to Methoxamine by Cooling in Isolated Dog Lingual and Mesenteric Arteries
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MIYOKO TSUKADA and SHIGETOSHI CHIBA
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Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390-8621
The effect of temperature on submaximal vasoconstrictions to an intraluminal injection of serotonin (5-HT) and methoxamine was investigated in isolated and perfused canine lingual and mesenteric arteries, using the cannula insertion method. In both arteries cooling (from 37°C to 27#176;C) caused a remarkable enhancement of vasoconstriction to 5-HT, but did not to methoxamine. In lingual arteries, methoxamine-induced constrictions were strongly depressed, although those were slightly depressed in mesenteric arteries. It is assumed that 5-HT produces an important role to modulate vascular tonicity in low temperature conditions.
Key words---
cannula insertion method; canine lingual artery; mesenteric artery; cooling; 5-HT
© 2000 Tohoku University Medical Press
Tohoku J. Exp. Med., 2000, 191, 139-144
Address for reprints: Shigetoshi Chiba, Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
e-mail: Chiba@sch.md.shinshu-u.ac.jp
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