THE


TOHOKU JOURNAL

OF

EXPERIMENTAL MEDICINE


Vol. 220, No. 2 FEBRUARY 2010

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TJEM Reviews


2010


Immunization Therapy for Alzheimer Disease: A Comprehensive Review of Active Immunization Strategies
Takeshi Tabira

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Vol. 220, No. 2
pp. 95-106, 2010
Pleiotropic Actions of Helicobacter pylori Vacuolating Cytotoxin, VacA.
Hajime Isomoto, Joel Moss and Toshiya Hirayama

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Vol. 220, No. 1
pp. 3-14, 2010

2009


Cisplatin Ototoxicity and Protection: Clinical and Experimental Studies.
Leonard P Rybak, Debashree Mukherjea, Sarvesh Jajoo and Vickram Ramkumar

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Vol. 219, No. 3
pp.177-186, 2009
Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy.
Kenta Ito, Yoshihiro Fukumoto and Hiroaki Shimokawa

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Vol. 219, No. 1
pp.1-9, 2009
Ischemic Colitis: Surging Waves of Update.
Michael Stamatakos, Emmanuel Douzinas, Charikleia Stefanaki, Constantina Petropoulou, Helen Arampatzi, Constantinos Safioleas, George Giannopoulos, Constantinos Chatziconstantinou, Constantinos Xiromeritis and Michael Safioleas

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Vol. 218, No. 2
pp.83-92, 2009
Undesirable Events With Radiopharmaceuticals.
Ralph Santos-Oliveira

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Vol. 217, No. 4
pp.251-257, 2009

2008


The Logistics Management and Coordination in Procurement Phase of Organ Transplantation.
R. GenE

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Vol. 216, No. 4
pp.287-296, 2008
Mesenteric Ischemia: Still a Deadly Puzzle for the Medical Community.
M. Stamatakos, C. Stefanaki, D. Mastrokalos, H. Arampatzi, P. Safioleas, C. Chatziconstantinou, C. Xiromeritis and M. Safioleas

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Vol. 216, No. 3
pp.197-204, 2008
Delusions and Visual Hallucinations in Dementia Patients: Focus on Personal History of the Patients.
M.-C. Pai

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Vol. 216, No. 1
pp.1-5, 2008
Angiotensin-Converting Enzyme Gene in Alzheimer's Disease.
Y.-H. Yang and C.-K. Liu

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Vol. 215, No. 4
pp.295-298, 2008
Neuroimaging in Dementia: In Vivo Amyloid Imaging.
T. Suhara, M. Higuchi and M. Miyoshi

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Vol. 215, No. 2
pp.119-124, 2008
Clinical Features of Mild Cognitive Impairment and Dementia in a Community: An update of the Osaki-Tajiri Project.
K. Meguro

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Vol. 215, No. 2
pp.125-131, 2008
Memory Impairment and Awareness of Memory Deficits in Early-Stage Alzheimer's Disease.
M. Mimura

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Vol. 215, No. 2
pp.133-140, 2008
Anosognosia for Amnesia as a Clue to Understand the Nature of Dementia.
A. Yamadori

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Vol. 215, No. 2
pp.141-147, 2008
First Disclosure of Lipid Droplet Substructure and Myelin Translucency in Embedment-Free Section Electron Microscopy.
H. Kondo, H. Iwasa and S. Saino-Saito

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Vol. 214, No.3,
pp.167-174, 2008
Molecular Mechanisms Governing Competitive Synaptic Wiring in Cerebellar Purkinje Cells.
M. Watanabe

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Vol. 214, No.3,
pp.175-190, 2008
The EFA6 Family: Guanine Nucleotide Exchange Factors for ADP Ribosylation Factor 6 at Neuronal Synapses.
H. Sakagami

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Vol. 214, No.3,
pp.191-198, 2008
Lipid Messenger, Diacylglycerol, and its Regulator, Diacylglycerol Kinase, in Cells, Organs, and Animals: History and Perspective.
K. Goto, Y. Hozumi, T. Nakano, S. Saino-Saito and A. M. Martelli

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Vol. 214, No.3,
pp.199-212, 2008
Fatty Acid Binding Protein: Localization and Functional Significance in the Brain.
Y. Owada

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Vol. 214, No.3,
pp.213-220, 2008

2007


Assessment of Intrauterine Methylmercury Exposure Affecting Child Development: Messages from the Newborn.
K. Murata, M. Dakeishi, M. Shimada and H. Satoh

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Vol. 213, No.3,
pp.187-202, 2007
Heme as a Magnificent Molecule with Multiple Missions: Heme Determines Its Own Fate and Governs Cellular Homeostasis.
K. Furuyama, K. Kaneko and P.D. Vargas V.

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Vol. 213, No.1,
pp.1-16, 2007
Problems with Registration-Directed Clinical Trials for Lung Cancer in Japan.
I. Sekine, H. Nokihara, N. Yamamoto, H. Kunitoh, Y. Ohe, N. Saijo and T. Tamura

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Vol. 213, No.1,
pp.17-23, 2007
The Decreasing Burden of Gastric Cancer in Japan.
M. Matsuzaka, S. Fukuda, I. Takahashi, S. Shimaya, T. Oyama, M. Yaegaki, T. Shimoyama, J. Sakamoto, S. Nakaji and T. Umeda

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Vol. 212, No.3,
pp.207-219, 2007
Hormone Replacement Therapy and Cancers: The Biological Roles of Estrogen and Progestin in Tumorigenesis are Different between the Endometrium and Breast.
K. Ito

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Vol. 212, No.1,
pp.1-12, 2007
Recent Progress in the Treatment of Pulmonary Arterial Hypertension: Expectation for Rho-Kinase Inhibitors.
Y. Fukumoto, S. Tawara and H. Shimokawa

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Vol. 211, No.4,
pp.309-320, 2007
Neuroendocrine Functions of Melanocytes: Beyond the Skin-Deep Melanin Maker.
K. Takeda, N. Takahashi and S. Shibahara

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Vol. 211, No.3,
pp.201-221, 2007
Current Malaria Status and Distribution of Drug Resistance in East and Southeast Asia with Special Focus to Thailand.
K. Na-Bangchang and K. Congpuong

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Vol. 211, No.2,
pp.99-113, 2007

2006


Management of the Pain Associated with Endometriosis: An Update of the Painful Problems.
Y. Ozawa, T. Murakami, Y. Terada, N. Yaegashi, K. Okamura, S. Kuriyama and I. Tsuji

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Vol. 210, No.3,
pp.175-188, 2006
GATA Transcription Factors and Hematological Diseases.
H. Harigae

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Vol. 210, No.1,
pp.1-9, 2006
Airway Remodeling in Asthma and its Influence on Clinical Pathophysiology.
K. Yamauchi

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Vol. 209, No.2,
pp.75-87, 2006
Kidney Dysfunction and Hypertension: Role for Cadmium, P450 and Heme Oxygenases?
S. Satarug, M. Nishijo, J.M. Lasker, R.J. Edwards and M.R. Moore

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Vol. 208, No.3,
pp.179-202, 2006
Genetically Modified Dendritic Cells for Therapeutic Immunity.
T. Kikuchi

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Vol. 208, No.1,
pp.1-8, 2006

2005


The Role of the Thymus in the Pathogenesis of Myasthenia Gravis.
H. Onodera

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Vol. 207, No.2,
pp.87-98, 2005
Preventive Strategies for Aspiration Pneumonia in Elderly Disabled Persons.
T. Ohrui

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Vol. 207, No.1,
pp.3-12, 2005
Aquisition, Mobilization and Utilization of Cellular Iron and Heme: Endless Findings and Growing Evidence of Tight Regulation.
S. Taketani

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Vol. 205, No.4,
pp.297-318, 2005
Medical Treatments and Cares for Geriatric Syndrome: New Strategies Learned from Frail Elderly.
H. Kubo, K. Nakayama, S. Ebihara and H. Sasaki

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Vol. 205, No.3,
pp.205-214, 2005

2004


Melanoma and the Problem of Malignancy.
P.A. Riley

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Vol. 204, No.1,
pp.1-9, 2004
Understanding Glial Differentiation in Vertebrate Nervous System Development.
Y. Wakamatsu

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Vol. 203, No.4,
pp.233-240, 2004
Gene-Based Deafness Research: Ion Transport and Hearing.
K. Ikeda

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Vol. 202, No.1,
pp.1-12, 2004

2003


Behavioral Teratology of Mercury and Its Compounds.
H. Satoh

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Vol. 201, No.1,
pp.1-9, 2003
The Heme Oxygenase Dilemma in Cellular Homeostasis: New Insights for the Feedback Regulation of Heme Catabolism.
S. Shibahara
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Vol. 200, No.4,
pp.167-186, 2003
Inflammatory Mechanisms in Bronchial Asthma and COPD.
M. Ichinose
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Vol. 200, No.1,
1-6, 2003

2002


Pathogenesis and Management of Virus Infection-Induced Exacerbation of Senile Bronchial Asthma and Chronic Pulmonary Emphysema.
M. Yamaya

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Vol. 197, No.2,
pp.67-80, 2002
Molecular Biology of Blood Pressure Regulatory Genes.
K. Takeuchi

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Vol. 197, No.1,
pp.1-8, 2002
Lead, Chemical Porphyria, and Heme as a Biological Mediator.
H. Fujita, C. Nishitani and K. Ogawa

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Vol. 196, No.2,
pp.53-64, 2002
Investigation of Intracellular Factors Involved in Methylmercury Toxicity.
A. Naganuma, T. Furuchi, N. Miura, G.-W. Hwang and S. Kuge

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Vol. 196, No.2,
pp.65-70, 2002
Modification of Mercury Toxicity by Selenium: Practical Importance?
C. Watanabe

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Vol. 196, No.2,
pp.71-77, 2002
Placental to Fetal Transfer of Mercury and Fetotoxicity.
M. Yoshida

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Vol. 196, No.2,
pp.79-88, 2002
Developmental Neurotoxicity Following Prenatal Exposures to Methylmercury and PCBs in Humans from Epidemiological Studies.
K. Nakai and H. Satoh

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Vol. 196, No.2,
89-98, 2002
Paradigm Shift in Zinc: Metal Pathology.
S. Onosaka, N. Tetsuchikawahara and K.-S. Min

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Vol. 196, No.1,
pp.1-8, 2002
Recent Studies on Metallothionein: Protection Against Toxicity of Heavy Metals and Oxygen Free Radicals.
M. Sato and M. Kondoh

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Vol. 196, No.1,
9-22, 2002
Perspectives on Cadmium Toxicity Research.
M. Satoh, H. Koyama, T. Kaji, H. Kito and C. Tohyama

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Vol. 196, No.1,
pp.23-32, 2002
Effects of Cadmium Intake on Bone Metabolism of Mothers during Pregnancy and Lactation.
H. Ohta, M. Ichikawa and Y. Seki

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Vol. 196, No.1,
pp.33-42, 2002
Cellular Cadmium Uptake Mediated by the Transport System for Manganese.
S. Himeno, T. Yanagiya, S. Enomoto, Y. Kondo and N. Imura

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Vol. 196, No.1,
pp.43-50, 2002

2001


Studies on Functional Roles of the Histaminergic Neuron System by Using Pharmacological Agents, Knockout Mice and Positron Emission Tomography.
T. Watanabe and K. Yanai
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Vol. 195, No.4,
pp.197-217, 2001
Adverse Effects of Smoking in the Renal Patient.
S.R. Orth, C. Viedt and E. Ritz
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Vol. 194, No.1,
pp.1-15, 2001
The Role of Pax6 in Brain Patterning.
N. Osumi
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Vol. 193, No.3,
pp.163-174, 2001
Adrenomedullin from a Pheochromocytoma to the Eye: Implications of the Adrenomedullin Research for Endocrinology in the 21st Century.
K. Takahashi
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Vol. 193, No.2,
pp.79-114, 2001

2000


Celiac Plexus Block in Cancer Pain Management.
M. Yamamuro, K. Kusaka, M. Kato and M. Takahashi

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Vol. 192, No.1,
pp.1-18, 2000
Genetic Determination of Human Essential Hypertension.
M. Matsubara

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Vol. 192, No.1,
pp.19-33, 2000
Inflammatory and Immune reactions Associated with Stratum Corneum and Neutrophils in Sterile Pustular Dermatoses.
T. Terui

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Vol. 190, No.4,
pp.239-248, 2000
Pathogenesis of nonimmune hydrops fetalis caused by intrauterine B19 infection.
N. Yaegashi

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Vol. 190, No.2,
pp.65-82, 2000

1999


Specific Targeting Immunotherapy of Cancer with Bispecific Antibodies.
T. Kudo, M.Suzuki, Y. Katayose, M. Shinoda, N. Sakurai, H. Kodama, M. Ichiyama, S. Takemura, H. Yoshida, H. Saeki, S. Saijyo, J. Takahashi, T. Tominaga and S.Matsuno

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Vol. 188, No.4,
pp.275-288, 1999
Breast-Conserving Surgery for Invasive Cancer: A Principle Based on Segmental Anatomy.
N. Ohuchi

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Vol. 188, No.2,
pp.103-118, 1999
Pathophysiologic significance of host reactions in human cancer tissue: Desmoplasia and tumor immunity.
H. Ohtani

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Vol. 187, No.3,
pp.193-202, 1999

1998


New strategies of screening and treatment for sleep apnea syndrome.
W. Hida

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Vol. 186, No.4,
pp.225 -241, 1998
Effects of air pollution and smoking on chronic obstructive pulmonary disease and bronchial asthma.
H. Sasaki, K. Sekizawa, M. Yanai, H. Arai, M. Yamaya and T. Ohrui

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Vol. 186, No.3,
pp.151-167, 1998
Maturation of dendritic cells induced by cytokines and haptens.
S. Aiba

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Vol. 184, No.3,
pp.159-172, 1998
Mechanisms and prevention of pneumonia in the elderly.
K. Sekizawa

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Vol. 184, No.2,
pp.73-84, 1998

1997


Molecular mechanism of heme biosynthesis.
H. Fujita

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Vol. 183, No.2,
pp.83-89, 1997
Clinical and molecular analysis of neurodegenerative diseases.
K. Abe

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Vol. 181, No.4,
pp.389-409, 1997
Abnormal lipid metabolism and renal disorders.
T. Saito

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Vol. 181, No.3,
pp.321-337, 1997


PUBLISHED BY TOHOKU UNIVERSITY MEDICAL PRESS, SENDAI, JAPAN

This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result from the Japan Society for the Promotion of Science.