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TJEM Reviews

GATA Transcription Factors: Basic Principles and Related Human Disorders
Tohru Fujiwara
Vol. 242, No. 2
pp.83-91, 2017
Membrane Trafficking Illuminates a Path to Parkinson’s Disease
Takafumi Hasegawa, Naoto Sugeno, Akio Kikuchi, Toru Baba and Masashi Aoki
Vol. 242, No. 1
pp.63-76, 2017
Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm
Soisungwan Satarug, David A. Vesey and Glenda C. Gobe
Vol. 241, No. 1
pp.65-87, 2016

Expression of CYP11B2 in Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance
Yasuhiro Nakamura, Yuto Yamazaki, Yuta Tezuka, Fumitoshi Satoh and Hironobu Sasano
Vol. 240, No. 3
pp.183-190, 2016
Therapeutic Benefits of Laughter in Mental Health: A Theoretical Review
JongEun Yim
Vol. 239, No. 3
pp.243-249, 2016
Pathological Effects of the FMR1 CGG-Repeat Polymorphism (5-55 Repeat Numbers): Systematic Review and Meta-Analysis
Wenjing Yang, Cuihua Fan, Liangyuan Chen, Zhaolei Cui, Ye Bai, Fenghua Lan
Vol. 239, No. 1
pp.57-66, 2016
Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin
Upa Kukongviriyapan, Kwanjit Apaijit, Veerapol Kukongviriyapan
Vol. 239, No. 1
pp.25-38, 2016
Development of Point-of-Care Testing for Disaster-Related Infectious Diseases
Toshio Hattori, Haorile Chagan-Yasutan, Beata Shiratori, Shinichi Egawa, Takako Izumi, Toru Kubo, Chie Nakajima, Yasuhiko Suzuki, Toshiro Niki, Bachti Alisjahbana and Elizabeth Telan
Vol. 238, No. 4
pp.287-293, 2016
Prevention of Tetanus Outbreak Following Natural Disaster in Indonesia: Lessons Learned from Previous Disasters
Dyshelly Nurkartika, Aya Murakami, Haorile Chagan-Yasutan, Toshio Hattori, Hiroyuki Sasaki and Shinichi Egawa
Vol. 238, No. 3
pp.219-227, 2016
Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders
Dongjuan Liu, Xin Zhao, Xin Zeng, Hongxia Dan1, and Qianming Chen
Vol. 238, No. 2
pp.165-177, 2016

Aftereffects of Subduction-Zone Earthquakes: Potential Tsunami Hazards along the Japan Sea Coast
Koji Minoura, Daisuke Sugawara, Toru Yamanoi and Tsutomu Yamada
Vol. 237, No. 2
pp.91-102, 2015
Pretreatment Screening for Hepatitis B Virus Infection in Patients with Systemic Lupus Erythematosus
Ryu Watanabe, Tomonori Ishii and Hideo Harigae
Vol. 237, No. 1
pp.9-15, 2015
TNF Receptor-Associated Factor (TRAF) Signaling Network in CD4+ T-Lymphocytes
Takanori So, Hiroyuki Nagashima and Naoto Ishii
Vol. 236, No. 2
pp.139-154, 2015
Current Status of Revascularization Surgery for Moyamoya Disease: Special Consideration for Its 'Internal Carotid-External Carotid (IC-EC) Conversion' as the Physiological Reorganization System
Miki Fujimura and Teiji Tominaga
Vol. 236, No. 1
pp.45-53, 2015
Erythropoietin Gene Expression: Developmental-stage Specificity, Cell-type Specificity, and Hypoxia Inducibility
Norio Suzuki
Vol. 235, No. 3
pp.233-240, 2015
Cyclophilin A in Cardiovascular Homeostasis and Diseases
Kimio Satoh
Vol. 235, No. 1
pp.1-15, 2015

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease
Feng Xu, Yaning Sun, Rui Shang, Minghua Li, Lianqun Cui, Zhaoqiang Cui and Yuguo Chen
Vol. 234, No. 2
pp.143-150, 2014
Central Hemodynamics and Target Organ Damage in Hypertension
Junichiro Hashimoto
Vol. 233, No. 1
pp.1-8, 2014
Cytotoxic and Targeted Systemic Therapy in Advanced and Recurrent Cervical Cancer: Experience from Clinical Trials
Hyun-Joo Seol, Roshani Ulak, Kyung-Do Ki and Jong-Min Lee
Vol. 232, No. 4
pp.232-269, 2014
Wearing Red for Signaling: The Heme-Bach Axis in Heme Metabolism, Oxidative Stress Response and Iron Immunology
Kazuhiko Igarashi, and Miki Watanabe-Matsui
Vol. 232, No. 4
pp.229-253, 2014
Elderly Health and Literature Therapy: A Theoretical Review
Yeongcheo Eum Jongeun Yim and Wonjae Choi
Vol. 232, No. 2
pp.79-83, 2014
Genetics of Pancreatitis: The 2014 Update
Atsushi Masamune
Vol. 232, No. 2
pp.69-77, 2014


Pioneering and Fundamental Achievements on the Development of Positron Emission Tomography (PET) in Oncology
Hiroshi Fukuda, Kazuo Kubota, Taiju Matsuzawa

Vol. 230, No. 3
pp.155-169, 2013
Myofibroblasts: Biochemical and Proteomic Approaches to Fibrosis
Eiko Honda, Ah-Mee Park, Koji Yoshida, Masaki Tabuchi, Hiroshi Munakata

Vol. 230, No. 2
pp.67-73, 2013
The Great East-Japan Earthquake and Devastating Tsunami: An Update and Lessons from the Past Great Earthquakes in Japan since 1923
Akemi Ishigaki, Hikari Higashi, Takako Sakamoto, Shigeki Shibahara

Vol. 229, No. 4
pp.287-299, 2013
DNA Methylation in Cancer: A Gene Silencing Mechanism and the Clinical Potential of Its Biomarkers
Shinichi Fukushige, Akira Horii

Vol. 229, No. 3
pp.173-185, 2013
Epigenetic Modifications in Hepatic Stellate Cells Contribute to Liver Fibrosis
Qi Zhao, Cheng-Yong Qin, Ze-Hua Zhao, Yu-Chen Fan, Kai Wang

Vol. 229, No. 1
pp.35-43, 2013


Emerging Roles of Cadmium and Heme Oxygenase in Type-2 Diabetes and Cancer Susceptibility
Soisungwan Satarug, Michael R. Moore

Vol. 228, No. 4
pp.267-288, 2012
New Lessons of Nurturing Life for Geriatric Patients
James P. Butler, Masahiko Fujii, Hidetada Sasaki

Vol. 227, No. 3
pp.203-210, 2012
Current Perspectives on Protective Roles of Erythropoietin in Cardiovascular System: Erythropoietin Receptor as a Novel Therapeutic Target
Yutaka Kagaya, Yasuhide Asaumi, Wanting Wang, Morihiko Takeda, Makoto Nakano, Kimio Satoh, Yoshihiro Fukumoto, Hiroaki Shimokawa

Vol. 227, No. 2
pp.83-91, 2012
Dentistry and Molecular Biology: A Promising Field for Tooth Agenesis Management
Breno Ramos Boeira Junior and Sergio Echeverrigaray

Vol. 226, No. 4
pp.243-249, 2012
Fluoroquinolone-Induced Tendinopathy: Etiology and Preventive Measures
Ferda Kaleagasioglu and Ercan Olcay

Vol. 226, No. 4
pp.251-258, 2012
The Current Endeavors to Understand the Pathogenesis of Intractable Liver Diseases
Yoshiyuki Ueno

Vol. 226, No. 3
pp.171-175, 2012
Primate Model Research for Endometriosis
Akiyoshi Yamanaka, Fuminori Kimura, Akie Takebayashi, Nobuyuki Kita, Kentaro Takahashi and Takashi Murakami

Vol. 226, No. 2
pp. 95-99, 2012


Transport of Nanoparticles through the Placental Barrier
Vytautas Kulvietis, Violeta Zalgeviciene, Janina Didziapetriene and Ricardas Rotomskis

Vol. 225, No. 4
pp. 225-234, 2011
Tonsillectomy and Steroid Pulse Therapy for IgA Nephropathy
Takahito Moriyama and Kosaku Nitta

Vol. 224, No. 4
pp. 243-250, 2011
Clinical Applications of Sentinel Lymph Node Biopsy in Ductal Carcinoma in situ of the Breast: A Dilemma
Yu Tang, Fei Xu, Kaishan Tao, Niansong Qian and Masakazu Toi

Vol. 224, No. 1
pp. 1-5, 2011
Aortic Arch Calcification and Clinical Outcome in Patients with End-Stage Renal Disease
Kosaku Nitta and Tetsuya Ogawa

Vol. 223, No. 2
pp. 79-84, 2011


Prevalence, Classification, and Etiology of Pain in Parkinson's Disease: Association between Parkinson's Disease and Fibromyalgia or Chronic Widespread Pain
Katsuhiro Toda and Toshihide Harada

Vol. 222, No. 1
pp. 1-5, 2010
Geriatric Medicine, Japanese Alzheimer's Disease Neuroimaging Initiative and Biomarker Development
Hiroyuki Arai, Nobuyuki Okamura, Katsutoshi Furukawa and Yukitsuka Kudo

Vol. 221, No. 2
pp. 87-95, 2010
Development of New Anti-tuberculosis Drug Candidates
Ruiru Shi and Isamu Sugawara

Vol. 221, No. 2
pp. 97-106, 2010
Genetic Bases for Glaucoma
Nobuo Fuse

Vol. 221, No. 1
pp. 1-10, 2010
The Advantages and Disadvantages of Sfrp1 and Sfrp2 Expression in Pathological Events
Pilar Esteve and Paola Bovolenta

Vol. 221, No. 1
pp. 11-17, 2010
Laparoscopic Adrenalectomy: Where Do We Stand Now?
Evridiki Karanikola, Christos Tsigris, Konstantinos Kontzoglou and Nikolaos Nikiteas

Vol. 220, No. 4
pp. 247-258, 2010
Essential Roles of the Sperm Centrosome in Human Fertilization: Developing the Therapy for Fertilization Failure due to Sperm Centrosomal Dysfunction
Yukihiro Terada, Gerald Schatten, Hisataka Hasegawa and Nobuo Yaegashi

Vol. 220, No. 4
pp. 259-265, 2010
Immunization Therapy for Alzheimer Disease: A Comprehensive Review of Active Immunization Strategies
Takeshi Tabira

Vol. 220, No. 2
pp. 95-106, 2010
Pleiotropic Actions of Helicobacter pylori Vacuolating Cytotoxin, VacA.
Hajime Isomoto, Joel Moss and Toshiya Hirayama

Vol. 220, No. 1
pp. 3-14, 2010


Cisplatin Ototoxicity and Protection: Clinical and Experimental Studies.
Leonard P Rybak, Debashree Mukherjea, Sarvesh Jajoo and Vickram Ramkumar

Vol. 219, No. 3
pp.177-186, 2009
Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy.
Kenta Ito, Yoshihiro Fukumoto and Hiroaki Shimokawa

Vol. 219, No. 1
pp.1-9, 2009
Ischemic Colitis: Surging Waves of Update.
Michael Stamatakos, Emmanuel Douzinas, Charikleia Stefanaki, Constantina Petropoulou, Helen Arampatzi, Constantinos Safioleas, George Giannopoulos, Constantinos Chatziconstantinou, Constantinos Xiromeritis and Michael Safioleas

Vol. 218, No. 2
pp.83-92, 2009
Undesirable Events With Radiopharmaceuticals.
Ralph Santos-Oliveira

Vol. 217, No. 4
pp.251-257, 2009


The Logistics Management and Coordination in Procurement Phase of Organ Transplantation.
R. GenE

Vol. 216, No. 4
pp.287-296, 2008
Mesenteric Ischemia: Still a Deadly Puzzle for the Medical Community.
M. Stamatakos, C. Stefanaki, D. Mastrokalos, H. Arampatzi, P. Safioleas, C. Chatziconstantinou, C. Xiromeritis and M. Safioleas

Vol. 216, No. 3
pp.197-204, 2008
Delusions and Visual Hallucinations in Dementia Patients: Focus on Personal History of the Patients.
M.-C. Pai

Vol. 216, No. 1
pp.1-5, 2008
Angiotensin-Converting Enzyme Gene in Alzheimer's Disease.
Y.-H. Yang and C.-K. Liu

Vol. 215, No. 4
pp.295-298, 2008
Neuroimaging in Dementia: In Vivo Amyloid Imaging.
T. Suhara, M. Higuchi and M. Miyoshi

Vol. 215, No. 2
pp.119-124, 2008
Clinical Features of Mild Cognitive Impairment and Dementia in a Community: An update of the Osaki-Tajiri Project.
K. Meguro

Vol. 215, No. 2
pp.125-131, 2008
Memory Impairment and Awareness of Memory Deficits in Early-Stage Alzheimer's Disease.
M. Mimura

Vol. 215, No. 2
pp.133-140, 2008
Anosognosia for Amnesia as a Clue to Understand the Nature of Dementia.
A. Yamadori

Vol. 215, No. 2
pp.141-147, 2008
First Disclosure of Lipid Droplet Substructure and Myelin Translucency in Embedment-Free Section Electron Microscopy.
H. Kondo, H. Iwasa and S. Saino-Saito

Vol. 214, No.3,
pp.167-174, 2008
Molecular Mechanisms Governing Competitive Synaptic Wiring in Cerebellar Purkinje Cells.
M. Watanabe

Vol. 214, No.3,
pp.175-190, 2008
The EFA6 Family: Guanine Nucleotide Exchange Factors for ADP Ribosylation Factor 6 at Neuronal Synapses.
H. Sakagami

Vol. 214, No.3,
pp.191-198, 2008
Lipid Messenger, Diacylglycerol, and its Regulator, Diacylglycerol Kinase, in Cells, Organs, and Animals: History and Perspective.
K. Goto, Y. Hozumi, T. Nakano, S. Saino-Saito and A. M. Martelli

Vol. 214, No.3,
pp.199-212, 2008
Fatty Acid Binding Protein: Localization and Functional Significance in the Brain.
Y. Owada

Vol. 214, No.3,
pp.213-220, 2008


Assessment of Intrauterine Methylmercury Exposure Affecting Child Development: Messages from the Newborn.
K. Murata, M. Dakeishi, M. Shimada and H. Satoh

Vol. 213, No.3,
pp.187-202, 2007
Heme as a Magnificent Molecule with Multiple Missions: Heme Determines Its Own Fate and Governs Cellular Homeostasis.
K. Furuyama, K. Kaneko and P.D. Vargas V.

Vol. 213, No.1,
pp.1-16, 2007
Problems with Registration-Directed Clinical Trials for Lung Cancer in Japan.
I. Sekine, H. Nokihara, N. Yamamoto, H. Kunitoh, Y. Ohe, N. Saijo and T. Tamura

Vol. 213, No.1,
pp.17-23, 2007
The Decreasing Burden of Gastric Cancer in Japan.
M. Matsuzaka, S. Fukuda, I. Takahashi, S. Shimaya, T. Oyama, M. Yaegaki, T. Shimoyama, J. Sakamoto, S. Nakaji and T. Umeda

Vol. 212, No.3,
pp.207-219, 2007
Hormone Replacement Therapy and Cancers: The Biological Roles of Estrogen and Progestin in Tumorigenesis are Different between the Endometrium and Breast.
K. Ito

Vol. 212, No.1,
pp.1-12, 2007
Recent Progress in the Treatment of Pulmonary Arterial Hypertension: Expectation for Rho-Kinase Inhibitors.
Y. Fukumoto, S. Tawara and H. Shimokawa

Vol. 211, No.4,
pp.309-320, 2007
Neuroendocrine Functions of Melanocytes: Beyond the Skin-Deep Melanin Maker.
K. Takeda, N. Takahashi and S. Shibahara

Vol. 211, No.3,
pp.201-221, 2007
Current Malaria Status and Distribution of Drug Resistance in East and Southeast Asia with Special Focus to Thailand.
K. Na-Bangchang and K. Congpuong

Vol. 211, No.2,
pp.99-113, 2007


Management of the Pain Associated with Endometriosis: An Update of the Painful Problems.
Y. Ozawa, T. Murakami, Y. Terada, N. Yaegashi, K. Okamura, S. Kuriyama and I. Tsuji

Vol. 210, No.3,
pp.175-188, 2006
GATA Transcription Factors and Hematological Diseases.
H. Harigae

Vol. 210, No.1,
pp.1-9, 2006
Airway Remodeling in Asthma and its Influence on Clinical Pathophysiology.
K. Yamauchi

Vol. 209, No.2,
pp.75-87, 2006
Kidney Dysfunction and Hypertension: Role for Cadmium, P450 and Heme Oxygenases?
S. Satarug, M. Nishijo, J.M. Lasker, R.J. Edwards and M.R. Moore

Vol. 208, No.3,
pp.179-202, 2006
Genetically Modified Dendritic Cells for Therapeutic Immunity.
T. Kikuchi

Vol. 208, No.1,
pp.1-8, 2006


The Role of the Thymus in the Pathogenesis of Myasthenia Gravis.
H. Onodera

Vol. 207, No.2,
pp.87-98, 2005
Preventive Strategies for Aspiration Pneumonia in Elderly Disabled Persons.
T. Ohrui

Vol. 207, No.1,
pp.3-12, 2005
Aquisition, Mobilization and Utilization of Cellular Iron and Heme: Endless Findings and Growing Evidence of Tight Regulation.
S. Taketani

Vol. 205, No.4,
pp.297-318, 2005
Medical Treatments and Cares for Geriatric Syndrome: New Strategies Learned from Frail Elderly.
H. Kubo, K. Nakayama, S. Ebihara and H. Sasaki

Vol. 205, No.3,
pp.205-214, 2005


Melanoma and the Problem of Malignancy.
P.A. Riley

Vol. 204, No.1,
pp.1-9, 2004
Understanding Glial Differentiation in Vertebrate Nervous System Development.
Y. Wakamatsu

Vol. 203, No.4,
pp.233-240, 2004
Gene-Based Deafness Research: Ion Transport and Hearing.
K. Ikeda

Vol. 202, No.1,
pp.1-12, 2004


Behavioral Teratology of Mercury and Its Compounds.
H. Satoh

Vol. 201, No.1,
pp.1-9, 2003
The Heme Oxygenase Dilemma in Cellular Homeostasis: New Insights for the Feedback Regulation of Heme Catabolism.
S. Shibahara
Vol. 200, No.4,
pp.167-186, 2003
Inflammatory Mechanisms in Bronchial Asthma and COPD.
M. Ichinose
Vol. 200, No.1,
1-6, 2003


Pathogenesis and Management of Virus Infection-Induced Exacerbation of Senile Bronchial Asthma and Chronic Pulmonary Emphysema.
M. Yamaya

Vol. 197, No.2,
pp.67-80, 2002
Molecular Biology of Blood Pressure Regulatory Genes.
K. Takeuchi

Vol. 197, No.1,
pp.1-8, 2002
Lead, Chemical Porphyria, and Heme as a Biological Mediator.
H. Fujita, C. Nishitani and K. Ogawa

Vol. 196, No.2,
pp.53-64, 2002
Investigation of Intracellular Factors Involved in Methylmercury Toxicity.
A. Naganuma, T. Furuchi, N. Miura, G.-W. Hwang and S. Kuge

Vol. 196, No.2,
pp.65-70, 2002
Modification of Mercury Toxicity by Selenium: Practical Importance?
C. Watanabe

Vol. 196, No.2,
pp.71-77, 2002
Placental to Fetal Transfer of Mercury and Fetotoxicity.
M. Yoshida

Vol. 196, No.2,
pp.79-88, 2002
Developmental Neurotoxicity Following Prenatal Exposures to Methylmercury and PCBs in Humans from Epidemiological Studies.
K. Nakai and H. Satoh

Vol. 196, No.2,
89-98, 2002
Paradigm Shift in Zinc: Metal Pathology.
S. Onosaka, N. Tetsuchikawahara and K.-S. Min

Vol. 196, No.1,
pp.1-8, 2002
Recent Studies on Metallothionein: Protection Against Toxicity of Heavy Metals and Oxygen Free Radicals.
M. Sato and M. Kondoh

Vol. 196, No.1,
9-22, 2002
Perspectives on Cadmium Toxicity Research.
M. Satoh, H. Koyama, T. Kaji, H. Kito and C. Tohyama

Vol. 196, No.1,
pp.23-32, 2002
Effects of Cadmium Intake on Bone Metabolism of Mothers during Pregnancy and Lactation.
H. Ohta, M. Ichikawa and Y. Seki

Vol. 196, No.1,
pp.33-42, 2002
Cellular Cadmium Uptake Mediated by the Transport System for Manganese.
S. Himeno, T. Yanagiya, S. Enomoto, Y. Kondo and N. Imura

Vol. 196, No.1,
pp.43-50, 2002


Studies on Functional Roles of the Histaminergic Neuron System by Using Pharmacological Agents, Knockout Mice and Positron Emission Tomography.
T. Watanabe and K. Yanai
Vol. 195, No.4,
pp.197-217, 2001
Adverse Effects of Smoking in the Renal Patient.
S.R. Orth, C. Viedt and E. Ritz
Vol. 194, No.1,
pp.1-15, 2001
The Role of Pax6 in Brain Patterning.
N. Osumi
Vol. 193, No.3,
pp.163-174, 2001
Adrenomedullin from a Pheochromocytoma to the Eye: Implications of the Adrenomedullin Research for Endocrinology in the 21st Century.
K. Takahashi
Vol. 193, No.2,
pp.79-114, 2001


Celiac Plexus Block in Cancer Pain Management.
M. Yamamuro, K. Kusaka, M. Kato and M. Takahashi

Vol. 192, No.1,
pp.1-18, 2000
Genetic Determination of Human Essential Hypertension.
M. Matsubara

Vol. 192, No.1,
pp.19-33, 2000
Inflammatory and Immune reactions Associated with Stratum Corneum and Neutrophils in Sterile Pustular Dermatoses.
T. Terui

Vol. 190, No.4,
pp.239-248, 2000
Pathogenesis of nonimmune hydrops fetalis caused by intrauterine B19 infection.
N. Yaegashi

Vol. 190, No.2,
pp.65-82, 2000


Specific Targeting Immunotherapy of Cancer with Bispecific Antibodies.
T. Kudo, M.Suzuki, Y. Katayose, M. Shinoda, N. Sakurai, H. Kodama, M. Ichiyama, S. Takemura, H. Yoshida, H. Saeki, S. Saijyo, J. Takahashi, T. Tominaga and S.Matsuno

Vol. 188, No.4,
pp.275-288, 1999
Breast-Conserving Surgery for Invasive Cancer: A Principle Based on Segmental Anatomy.
N. Ohuchi

Vol. 188, No.2,
pp.103-118, 1999
Pathophysiologic significance of host reactions in human cancer tissue: Desmoplasia and tumor immunity.
H. Ohtani

Vol. 187, No.3,
pp.193-202, 1999


New strategies of screening and treatment for sleep apnea syndrome.
W. Hida

Vol. 186, No.4,
pp.225 -241, 1998
Effects of air pollution and smoking on chronic obstructive pulmonary disease and bronchial asthma.
H. Sasaki, K. Sekizawa, M. Yanai, H. Arai, M. Yamaya and T. Ohrui

Vol. 186, No.3,
pp.151-167, 1998
Maturation of dendritic cells induced by cytokines and haptens.
S. Aiba

Vol. 184, No.3,
pp.159-172, 1998
Mechanisms and prevention of pneumonia in the elderly.
K. Sekizawa

Vol. 184, No.2,
pp.73-84, 1998


Molecular mechanism of heme biosynthesis.
H. Fujita

Vol. 183, No.2,
pp.83-89, 1997
Clinical and molecular analysis of neurodegenerative diseases.
K. Abe

Vol. 181, No.4,
pp.389-409, 1997
Abnormal lipid metabolism and renal disorders.
T. Saito

Vol. 181, No.3,
pp.321-337, 1997


This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result from the Japan Society for the Promotion of Science(Grant Number JP252007).